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Effect of estradiol replacement on hippocampal concentrations of estrogens in aged rhesus macaques maintained on an obesogenic diet
- Source :
- Biochemistry and Biophysics Reports, Vol 35, Iss , Pp 101548- (2023)
- Publication Year :
- 2023
- Publisher :
- Elsevier, 2023.
-
Abstract
- Replacement involving estrogens has proven efficacy at treating a wide range of disorders that develop with menopause or after surgical removal of the ovaries. Here, we tested whether an estradiol (E2) replacement paradigm that recapitulates physiological E2 levels in the circulation also recapitulates physiological E2 levels within the hippocampus. E2 was delivered continuously to old ovariectomized (OVX) rhesus macaques, maintained on a high-fat, high-sugar Western-style diet (WSD) for ∼30 months, via subcutaneous implants; this resulted in physiological concentrations of both estrone (E1) and E2 in the circulation (determined by LC-MS/MS). Surprisingly, however, hippocampal concentrations of E2 were markedly (P
Details
- Language :
- English
- ISSN :
- 24055808
- Volume :
- 35
- Issue :
- 101548-
- Database :
- Directory of Open Access Journals
- Journal :
- Biochemistry and Biophysics Reports
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.b7245149fcbb4c74b48b305e964317ad
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.bbrep.2023.101548