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Protective and therapeutic effects of apigenin on thioacetamide-induced hepatotoxicity in male rats: physiological and morphological study

Authors :
Zaenah Zuhair Alamri
Source :
Egyptian Liver Journal, Vol 14, Iss 1, Pp 1-14 (2024)
Publication Year :
2024
Publisher :
SpringerOpen, 2024.

Abstract

Abstract Background Liver fibrosis is an irreversible liver destruction. Apigenin (API) has different pharmacological properties as anticancer, anti-inflammatory, and antioxidant; however, API hepatoprotective and therapeutic effects are not often studied. This study assesses protective and therapeutic API effects on hepatic injuries produced by thioacetamide (TAA) in rats. Methods Forty-nine rats were sorted into seven groups (7 in each): negative control (G1), positive control (G2, TAA), API group (G3), TAA+API group (G4), TAA+SL group (G5), API+TAA group (G6), and SL+TAA group (G7). API and SL effects on TAA-induced hepatotoxicity were examined by determined body weights, liver weights, complete blood count picture (white blood cells, red blood cells, hemoglobin, hematocrit, and platelets counts), liver function tests (alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, gamma glutamyl transferase, alkaline phosphatase, total proteins, albumin, and globulin), and oxidative stress markers (malonaldehyde, catalase, superoxide dismutase, and reduced glutathione) in serum and liver histological was assessed. Results TAA decreased red blood cells, platelets, hemoglobin content, and hematocrit (p

Details

Language :
English
ISSN :
20906226
Volume :
14
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Egyptian Liver Journal
Publication Type :
Academic Journal
Accession number :
edsdoj.b73d642146149cb94e73f314a292fa2
Document Type :
article
Full Text :
https://doi.org/10.1186/s43066-024-00318-7