Back to Search Start Over

Transcriptomics and magnetic resonance imaging in major psychiatric disorders

Authors :
Jing-Wen Fan
Yue-Wen Gu
Dong-Bao Wang
Xiao-Fan Liu
Shu-Wan Zhao
Xiao Li
Baojuan Li
Hong Yin
Wen-Jun Wu
Long-Biao Cui
Source :
Frontiers in Psychiatry, Vol 14 (2023)
Publication Year :
2023
Publisher :
Frontiers Media S.A., 2023.

Abstract

Major psychiatric disorders create a significant public health burden, and mental disorders such as major depressive disorder, bipolar disorder, and schizophrenia are major contributors to the national disease burden. The search for biomarkers has been a leading endeavor in the field of biological psychiatry in recent decades. And the application of cross-scale and multi-omics approaches combining genes and imaging in major psychiatric studies has facilitated the elucidation of gene-related pathogenesis and the exploration of potential biomarkers. In this article, we summarize the results of using combined transcriptomics and magnetic resonance imaging to understand structural and functional brain changes associated with major psychiatric disorders in the last decade, demonstrating the neurobiological mechanisms of genetically related structural and functional brain alterations in multiple directions, and providing new avenues for the development of quantifiable objective biomarkers, as well as clinical diagnostic and prognostic indicators.

Details

Language :
English
ISSN :
16640640
Volume :
14
Database :
Directory of Open Access Journals
Journal :
Frontiers in Psychiatry
Publication Type :
Academic Journal
Accession number :
edsdoj.b76bf0efed14482963b5f256036cea1
Document Type :
article
Full Text :
https://doi.org/10.3389/fpsyt.2023.1185471