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Study of Clinical Profile and Antibiotic Sensitivity Pattern in Culture-positive Typhoid Fever Cases
- Source :
- Indian Journal of Community Medicine, Vol 37, Iss 4, Pp 256-258 (2012)
- Publication Year :
- 2012
- Publisher :
- Wolters Kluwer Medknow Publications, 2012.
-
Abstract
- Background: Salmonella enteric serotype Typhi has created a significant therapeutic problem as these strains have developed resistance to the commonly used antimicrobials for the treatment of typhoid fever. Objectives: To assess the clinical profile and sensitivity patterns to anti-typhoid drugs. Materials and Methods: A retrospective analysis of 106 culture-positive typhoid cases admitted in a tertiary care hospital during the years 2005-2008. Results: Records of 106 patients were evaluated, 83 (78.3%) males and 23 (21.7%) females. Fever was present in all patients. Headache in 63 (59.4%) patients and generalized body ache in 53 (32.5%) patients were the most common symptoms, while spleenomegaly in 47 (44.3%) patients and hepatomegaly in 42 (39.6%) patients were the common presenting signs. A maximum sensitivity of 96.6% was observed with cephalosporins, whereas a resistance of 29.2% was seen with fluoroquinolones. Conclusion: A high degree of sensitivity was noted to chloramphenicol, ampicillin and sulphonamides, showing a trend of roll-back of sensitivity to conventional antibiotics.
Details
- Language :
- English
- ISSN :
- 09700218 and 19983581
- Volume :
- 37
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Indian Journal of Community Medicine
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.b7949727930045cdbb06eab1705fb858
- Document Type :
- article
- Full Text :
- https://doi.org/10.4103/0970-0218.103475