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Shared heritability and functional enrichment across six solid cancers

Authors :
Xia Jiang
Hilary K. Finucane
Fredrick R. Schumacher
Stephanie L. Schmit
Jonathan P. Tyrer
Younghun Han
Kyriaki Michailidou
Corina Lesseur
Karoline B. Kuchenbaecker
Joe Dennis
David V. Conti
Graham Casey
Mia M. Gaudet
Jeroen R. Huyghe
Demetrius Albanes
Melinda C. Aldrich
Angeline S. Andrew
Irene L. Andrulis
Hoda Anton-Culver
Antonis C. Antoniou
Natalia N. Antonenkova
Susanne M. Arnold
Kristan J. Aronson
Banu K. Arun
Elisa V. Bandera
Rosa B. Barkardottir
Daniel R. Barnes
Jyotsna Batra
Matthias W. Beckmann
Javier Benitez
Sara Benlloch
Andrew Berchuck
Sonja I. Berndt
Heike Bickeböller
Stephanie A. Bien
Carl Blomqvist
Stefania Boccia
Natalia V. Bogdanova
Stig E. Bojesen
Manjeet K. Bolla
Hiltrud Brauch
Hermann Brenner
James D. Brenton
Mark N. Brook
Joan Brunet
Hans Brunnström
Daniel D. Buchanan
Barbara Burwinkel
Ralf Butzow
Gabriella Cadoni
Trinidad Caldés
Maria A. Caligo
Ian Campbell
Peter T. Campbell
Géraldine Cancel-Tassin
Lisa Cannon-Albright
Daniele Campa
Neil Caporaso
André L. Carvalho
Andrew T. Chan
Jenny Chang-Claude
Stephen J. Chanock
Chu Chen
David C. Christiani
Kathleen B. M. Claes
Frank Claessens
Judith Clements
J. Margriet Collée
Marcia Cruz Correa
Fergus J. Couch
Angela Cox
Julie M. Cunningham
Cezary Cybulski
Kamila Czene
Mary B. Daly
Anna deFazio
Peter Devilee
Orland Diez
Manuela Gago-Dominguez
Jenny L. Donovan
Thilo Dörk
Eric J. Duell
Alison M. Dunning
Miriam Dwek
Diana M. Eccles
Christopher K. Edlund
Digna R Velez Edwards
Carolina Ellberg
D. Gareth Evans
Peter A. Fasching
Robert L. Ferris
Triantafillos Liloglou
Jane C. Figueiredo
Olivia Fletcher
Renée T. Fortner
Florentia Fostira
Silvia Franceschi
Eitan Friedman
Steven J. Gallinger
Patricia A. Ganz
Judy Garber
José A. García-Sáenz
Simon A. Gayther
Graham G. Giles
Andrew K. Godwin
Mark S. Goldberg
David E. Goldgar
Ellen L. Goode
Marc T. Goodman
Gary Goodman
Kjell Grankvist
Mark H. Greene
Henrik Gronberg
Jacek Gronwald
Pascal Guénel
Niclas Håkansson
Per Hall
Ute Hamann
Freddie C. Hamdy
Robert J. Hamilton
Jochen Hampe
Aage Haugen
Florian Heitz
Rolando Herrero
Peter Hillemanns
Michael Hoffmeister
Estrid Høgdall
Yun-Chul Hong
John L. Hopper
Richard Houlston
Peter J. Hulick
David J. Hunter
David G. Huntsman
Gregory Idos
Evgeny N. Imyanitov
Sue Ann Ingles
Claudine Isaacs
Anna Jakubowska
Paul James
Mark A. Jenkins
Mattias Johansson
Mikael Johansson
Esther M. John
Amit D. Joshi
Radka Kaneva
Beth Y. Karlan
Linda E. Kelemen
Tabea Kühl
Kay-Tee Khaw
Elza Khusnutdinova
Adam S. Kibel
Lambertus A. Kiemeney
Jeri Kim
Susanne K. Kjaer
Julia A. Knight
Manolis Kogevinas
Zsofia Kote-Jarai
Stella Koutros
Vessela N. Kristensen
Jolanta Kupryjanczyk
Martin Lacko
Stephan Lam
Diether Lambrechts
Maria Teresa Landi
Philip Lazarus
Nhu D. Le
Eunjung Lee
Flavio Lejbkowicz
Heinz-Josef Lenz
Goska Leslie
Davor Lessel
Jenny Lester
Douglas A. Levine
Li Li
Christopher I. Li
Annika Lindblom
Noralane M. Lindor
Geoffrey Liu
Fotios Loupakis
Jan Lubiński
Lovise Maehle
Christiane Maier
Arto Mannermaa
Loic Le Marchand
Sara Margolin
Taymaa May
Lesley McGuffog
Alfons Meindl
Pooja Middha
Austin Miller
Roger L. Milne
Robert J. MacInnis
Francesmary Modugno
Marco Montagna
Victor Moreno
Kirsten B. Moysich
Lorelei Mucci
Kenneth Muir
Anna Marie Mulligan
Katherine L. Nathanson
David E. Neal
Andrew R. Ness
Susan L. Neuhausen
Heli Nevanlinna
Polly A. Newcomb
Lisa F. Newcomb
Finn Cilius Nielsen
Liene Nikitina-Zake
Børge G. Nordestgaard
Robert L. Nussbaum
Kenneth Offit
Edith Olah
Ali Amin Al Olama
Olufunmilayo I. Olopade
Andrew F. Olshan
Håkan Olsson
Ana Osorio
Hardev Pandha
Jong Y. Park
Nora Pashayan
Michael T. Parsons
Tanja Pejovic
Kathryn L. Penney
Wilbert H M. Peters
Catherine M. Phelan
Amanda I. Phipps
Dijana Plaseska-Karanfilska
Miranda Pring
Darya Prokofyeva
Paolo Radice
Kari Stefansson
Susan J. Ramus
Leon Raskin
Gad Rennert
Hedy S. Rennert
Elizabeth J. van Rensburg
Marjorie J. Riggan
Harvey A. Risch
Angela Risch
Monique J. Roobol
Barry S. Rosenstein
Mary Anne Rossing
Kim De Ruyck
Emmanouil Saloustros
Dale P. Sandler
Elinor J. Sawyer
Matthew B. Schabath
Johanna Schleutker
Marjanka K. Schmidt
V. Wendy Setiawan
Hongbing Shen
Erin M. Siegel
Weiva Sieh
Christian F. Singer
Martha L. Slattery
Karina Dalsgaard Sorensen
Melissa C. Southey
Amanda B. Spurdle
Janet L. Stanford
Victoria L. Stevens
Sebastian Stintzing
Jennifer Stone
Karin Sundfeldt
Rebecca Sutphen
Anthony J. Swerdlow
Eloiza H. Tajara
Catherine M. Tangen
Adonina Tardon
Jack A. Taylor
M. Dawn Teare
Manuel R. Teixeira
Mary Beth Terry
Kathryn L. Terry
Stephen N. Thibodeau
Mads Thomassen
Line Bjørge
Marc Tischkowitz
Amanda E. Toland
Diana Torres
Paul A. Townsend
Ruth C. Travis
Nadine Tung
Shelley S. Tworoger
Cornelia M. Ulrich
Nawaid Usmani
Celine M. Vachon
Els Van Nieuwenhuysen
Ana Vega
Miguel Elías Aguado-Barrera
Qin Wang
Penelope M. Webb
Clarice R. Weinberg
Stephanie Weinstein
Mark C. Weissler
Jeffrey N. Weitzel
Catharine M. L. West
Emily White
Alice S. Whittemore
H-Erich Wichmann
Fredrik Wiklund
Robert Winqvist
Alicja Wolk
Penella Woll
Michael Woods
Anna H. Wu
Xifeng Wu
Drakoulis Yannoukakos
Wei Zheng
Shanbeh Zienolddiny
Argyrios Ziogas
Kristin K. Zorn
Jacqueline M. Lane
Richa Saxena
Duncan Thomas
Rayjean J. Hung
Brenda Diergaarde
James McKay
Ulrike Peters
Li Hsu
Montserrat García-Closas
Rosalind A. Eeles
Georgia Chenevix-Trench
Paul J. Brennan
Christopher A. Haiman
Jacques Simard
Douglas F. Easton
Stephen B. Gruber
Paul D. P. Pharoah
Alkes L. Price
Bogdan Pasaniuc
Christopher I. Amos
Peter Kraft
Sara Lindström
Source :
Nature Communications, Vol 10, Iss 1, Pp 1-23 (2019)
Publication Year :
2019
Publisher :
Nature Portfolio, 2019.

Abstract

Similarities in cancers can be studied to interrogate their etiology. Here, the authors use genome-wide association study summary statistics from six cancer types based on 296,215 cases and 301,319 controls of European ancestry, showing that solid tumours arising from different tissues share a degree of common germline genetic basis.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
10
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.b8cd2398d6804293b10da647205e9798
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-018-08054-4