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Pangenome Analysis Reveals a High Degree of Genetic Diversity in Gardnerella vaginalis: An In Silico Approach
- Source :
- Venereology, Vol 2, Iss 4, Pp 132-146 (2023)
- Publication Year :
- 2023
- Publisher :
- MDPI AG, 2023.
-
Abstract
- The genus Gardnerella comprises Gram-variable, anaerobic, hemolytic, and non-motile bacilli, with four known species, where Gardnerella vaginalis is the main species responsible for bacterial vaginosis (BV). However, quantifying this species is challenging due to a lack of data and underreporting. Despite its significance, particularly for women, and the availability of several genomes in online databases, genomic analyses and studies on effective treatments still lack details. This study aimed to conduct bioinformatic analyses focused on pangenomics to investigate the complete gene repertoire of the species. Genomes of the bacterium available in online databases were used for comparative genomics, genomic plasticity, gene synteny, and pangenome prediction analyses. The results revealed considerable genome variability, indicating a highly diverse pangenome. The low number of genes in the core genome and similarity analysis confirmed this variability. Three pathogenicity islands, two resistance islands, and nine genomic islands were identified, suggesting horizontal gene transfer events during evolution. These findings underscore the need for sequencing new G. vaginalis genomes to better comprehend its variability and adaptation patterns.
Details
- Language :
- English
- ISSN :
- 26740710
- Volume :
- 2
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Venereology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.b8f729110737490a809d3edb91c70d7b
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/venereology2040012