Back to Search Start Over

Targeted Metabolomics Revealed a Sex-Dependent Signature for Metabolic Syndrome in the Mexican Population

Authors :
Berenice Palacios-González
Guadalupe León-Reyes
Berenice Rivera-Paredez
Isabel Ibarra-González
Marcela Vela-Amieva
Yvonne N. Flores
Samuel Canizales-Quinteros
Jorge Salmerón
Rafael Velázquez-Cruz
Source :
Nutrients, Vol 14, Iss 18, p 3678 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Metabolic syndrome (MetS) is a group of several metabolic conditions predisposing to chronic diseases. Individuals diagnosed with MetS are physiologically heterogeneous, with significant sex-specific differences. Therefore, we aimed to investigate the potential sex-specific serum modifications of amino acids and acylcarnitines (ACs) and their relationship with MetS in the Mexican population. This study included 602 participants from the Health Workers Cohort Study. Forty serum metabolites were analyzed using a targeted metabolomics approach. Multivariate regression models were used to test associations of clinical and biochemical parameters with metabolomic profiles. Our findings showed a serum amino acid signature (citrulline and glycine) and medium-chain ACs (AC14:1, AC10, and AC18:10H) associated with MetS. Glycine and AC10 were specific metabolites representative of discrimination according to sex-dependent MetS. In addition, we found that glycine and short-chain ACs (AC2, AC3, and AC8:1) are associated with age-dependent MetS. We also reported a significant correlation between body fat and metabolites associated with sex-age-dependent MetS. In conclusion, the metabolic profile varies by MetS status, and these differences are sex-age-dependent in the Mexican population.

Details

Language :
English
ISSN :
20726643
Volume :
14
Issue :
18
Database :
Directory of Open Access Journals
Journal :
Nutrients
Publication Type :
Academic Journal
Accession number :
edsdoj.b942fc8bb841f68c2dea4bf0358f3c
Document Type :
article
Full Text :
https://doi.org/10.3390/nu14183678