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Transfer of dysbiotic gut microbiota has beneficial effects on host liver metabolism

Authors :
Simon Nicolas
Vincent Blasco‐Baque
Audren Fournel
Jerome Gilleron
Pascale Klopp
Aurelie Waget
Franck Ceppo
Alysson Marlin
Roshan Padmanabhan
Jason S Iacovoni
François Tercé
Patrice D Cani
Jean‐François Tanti
Remy Burcelin
Claude Knauf
Mireille Cormont
Matteo Serino
Source :
Molecular Systems Biology, Vol 13, Iss 3, Pp 1-17 (2017)
Publication Year :
2017
Publisher :
Springer Nature, 2017.

Abstract

Abstract Gut microbiota dysbiosis has been implicated in a variety of systemic disorders, notably metabolic diseases including obesity and impaired liver function, but the underlying mechanisms are uncertain. To investigate this question, we transferred caecal microbiota from either obese or lean mice to antibiotic‐free, conventional wild‐type mice. We found that transferring obese‐mouse gut microbiota to mice on normal chow (NC) acutely reduces markers of hepatic gluconeogenesis with decreased hepatic PEPCK activity, compared to non‐inoculated mice, a phenotypic trait blunted in conventional NOD2 KO mice. Furthermore, transferring of obese‐mouse microbiota changes both the gut microbiota and the microbiome of recipient mice. We also found that transferring obese gut microbiota to NC‐fed mice then fed with a high‐fat diet (HFD) acutely impacts hepatic metabolism and prevents HFD‐increased hepatic gluconeogenesis compared to non‐inoculated mice. Moreover, the recipient mice exhibit reduced hepatic PEPCK and G6Pase activity, fed glycaemia and adiposity. Conversely, transfer of lean‐mouse microbiota does not affect markers of hepatic gluconeogenesis. Our findings provide a new perspective on gut microbiota dysbiosis, potentially useful to better understand the aetiology of metabolic diseases.

Details

Language :
English
ISSN :
17444292
Volume :
13
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Molecular Systems Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.b955560a33e845d1b23e5d096d6e2b27
Document Type :
article
Full Text :
https://doi.org/10.15252/msb.20167356