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DNA methylation analysis explores the molecular basis of plasma cell-free DNA fragmentation

Authors :
Yunyun An
Xin Zhao
Ziteng Zhang
Zhaohua Xia
Mengqi Yang
Li Ma
Yu Zhao
Gang Xu
Shunda Du
Xiang’an Wu
Shuowen Zhang
Xin Hong
Xin Jin
Kun Sun
Source :
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

Cell free DNA is produced through a non-random process. Here, the authors use orientation-aware fragmentation analysis to identify DNA methylation as a regulator of nuclease function.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
14
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.b9632055ddd54a3f9f0a43ec3d13c260
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-023-35959-6