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SERCAP: is the perfect the enemy of the good?

Authors :
Nicholas J. White
François H. Nosten
Source :
Malaria Journal, Vol 20, Iss 1, Pp 1-4 (2021)
Publication Year :
2021
Publisher :
BMC, 2021.

Abstract

Abstract Single Encounter Radical Cure and Prophylaxis (SERCAP) describes an ideal anti-malarial drug that cures all malaria in a single dose. This target product profile has dominated anti-malarial drug discovery and development over the past decade. The operational advantage of a single encounter has to be balanced against the need for a high dose, reliable absorption, little variability in pharmacokinetic properties, slow elimination (to ensure curative drug exposures in all patients) and a very low rate of vomiting. The demanding aspirational target may have hindered anti-malarial drug development. Aiming for three-day regimens, as in current anti-malarial treatments, would be better.

Details

Language :
English
ISSN :
14752875
Volume :
20
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Malaria Journal
Publication Type :
Academic Journal
Accession number :
edsdoj.b98b1c0c5aae4839ab7e69a32365be0b
Document Type :
article
Full Text :
https://doi.org/10.1186/s12936-021-03821-z