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Association of Dietary Acid Load with the Prevalence of Metabolic Syndrome among Participants in Baseline Survey of the Japan Multi-Institutional Collaborative Cohort Study

Authors :
Kokichi Arisawa
Sakurako Katsuura-Kamano
Hirokazu Uemura
Nguyen Van Tien
Asahi Hishida
Takashi Tamura
Yoko Kubo
Mineko Tsukamoto
Keitaro Tanaka
Megumi Hara
Toshiro Takezaki
Daisaku Nishimoto
Teruhide Koyama
Etsuko Ozaki
Sadao Suzuki
Takeshi Nishiyama
Kiyonori Kuriki
Aya Kadota
Naoyuki Takashima
Hiroaki Ikezaki
Masayuki Murata
Isao Oze
Keitaro Matsuo
Haruo Mikami
Yohko Nakamura
Kenji Takeuchi
Kenji Wakai
Source :
Nutrients, Vol 12, Iss 6, p 1605 (2020)
Publication Year :
2020
Publisher :
MDPI AG, 2020.

Abstract

The association between dietary acid load and metabolic syndrome (MetS) has not been fully investigated. A cross-sectional study was performed on 14,042 men and 14,105 women (aged 35–69 years) who participated in a baseline survey of the Japan Multi-Institutional Collaborative Cohort study. Dietary acid load was assessed using the net-endogenous-acid-production (NEAP) score that is closely correlated with the rate of renal net acid excretion. MetS was diagnosed according to the Joint Interim Statement Criteria of 2009 using body-mass index instead of waist circumference. After adjusting for potential confounders, higher NEAP scores were associated with a significantly increased odds ratio (OR) of MetS, obesity, high blood pressure, and high fasting blood glucose. These associations remained significant after further adjustment for carbohydrate intake or two nutrient-pattern scores significantly associated with MetS. After adjustment for fiber, iron, potassium, and vitamin pattern scores, the OR of MetS for the highest quartile of NEAP scores, relative to the lowest quartile, was 1.25 (95% confidence interval 1.12–1.39). There was no significant interaction between sex, age, or body-mass index and NEAP. Higher dietary acid load was associated with a higher prevalence of MetS and several of its components, independently of carbohydrate intake or nutrient patterns.

Details

Language :
English
ISSN :
20726643
Volume :
12
Issue :
6
Database :
Directory of Open Access Journals
Journal :
Nutrients
Publication Type :
Academic Journal
Accession number :
edsdoj.b98b69d3154caea108d2eab53aea65
Document Type :
article
Full Text :
https://doi.org/10.3390/nu12061605