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Mapping genomic and transcriptomic alterations spatially in epithelial cells adjacent to human breast carcinoma

Authors :
Moustafa Abdalla
Danh Tran-Thanh
Juan Moreno
Vladimir Iakovlev
Ranju Nair
Nisha Kanwar
Mohamed Abdalla
Jennifer P. Y. Lee
Jennifer Yin Yee Kwan
Thomas R. Cawthorn
Keisha Warren
Nona Arneson
Dong-Yu Wang
Natalie S. Fox
Bruce J. Youngson
Naomi A. Miller
Alexandra M. Easson
David McCready
Wey L. Leong
Paul C. Boutros
Susan J. Done
Source :
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Publication Year :
2017
Publisher :
Nature Portfolio, 2017.

Abstract

Studying the spatial mutational and gene expression alterations in breast cancer could impact our understanding of breast cancer development. Here, the authors analyse a unique dataset of epithelial samples that highlight potential field cancerisation surrounding the primary tumour.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
8
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.ba4deac145a6bb91d719ca0af931
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-017-01357-y