Back to Search
Start Over
Established a therapeutic response prediction model in metastatic gastric cancer by liquid biopsy
- Source :
- Clinical and Translational Discovery, Vol 4, Iss 4, Pp n/a-n/a (2024)
- Publication Year :
- 2024
- Publisher :
- Wiley, 2024.
-
Abstract
- Abstract This study by Okuno et al. successfully identified eight exo‐miRNAs through exosome‐based discovery and established an exo‐miRNA‐based liquid biopsy assay for predicting therapeutic response in metastatic gastric cancer (mGC). Exosomes, a subpopulation of extracellular vesicles originating from endosomes, play a crucial role in this context. Liquid biopsy, analyzing blood for circulating tumor cells, extracellular vesicles, or cell‐free nucleic acid, has revolutionized cancer diagnosis and monitoring. It significantly contributes to early detection, staging, and relapse detection in various cancers. Numerous studies have highlighted the clinical significance of miRNA and lncRNA within extracellular vesicles. The authors developed a response‐prediction model for chemo‐responsiveness in mGC patients. This study's model predicts responses robustly, demonstrating its potential efficacy in clinical practice. It offers a non‐invasive and accessible method for therapeutic response prediction, crucial for precision medicine in mGC. Successful translation of these findings into clinical applications promises substantial benefits for patient care.
- Subjects :
- exosome
gastric cancer
liquild biopsy
Therapeutics. Pharmacology
RM1-950
Subjects
Details
- Language :
- English
- ISSN :
- 27680622
- Volume :
- 4
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Clinical and Translational Discovery
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.bab5c35c1243e6a36bc8127fa6e80d
- Document Type :
- article
- Full Text :
- https://doi.org/10.1002/ctd2.336