Sorry, I don't understand your search. ×
Back to Search Start Over

First-Trimester Plasmatic microRNAs Are Associated with Fasting Glucose Levels in Late Second Trimester of Pregnancy

Authors :
Cécilia Légaré
Véronique Desgagné
Kathrine Thibeault
Frédérique White
Andrée-Anne Clément
Cédrik Poirier
Zhong-Cheng Luo
Michelle S. Scott
Pierre-Étienne Jacques
Patrice Perron
Renée Guérin
Marie-France Hivert
Luigi Bouchard
Source :
Biomedicines, Vol 12, Iss 6, p 1285 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Maternal blood glucose regulation adaptation to pregnancy aims to support fetal growth but may also lead to the development of gestational diabetes mellitus, the most common pregnancy complication. MiRNAs are small RNA molecules secreted and stable in the blood, where they could have paracrine hormone-like functions (ribo-hormone) and regulate metabolic processes including fetal growth and glucose metabolism. The objective of this study was to identify plasmatic microRNA (miRNAs) measured during the first trimester of pregnancy that were associated with glucose levels during a 75 g oral glucose tolerance test (OGTT) at ~26 weeks of pregnancy. miRNAs were quantified using next-generation sequencing in 444 pregnant women and replicated in an independent cohort of 106 pregnant women. MiRNAs associated with glucose levels were identified with the DESeq2 package. We identified 24 miRNAs associated with fasting glycemia, of which 18 were common to both cohorts (q-value < 0.1). However, no association was found between miRNAs and 1 h or 2 h post OGTT glycemia. To conclude, we identified 18 miRNAs early in pregnancy that were associated with fasting blood glucose measured 3 months later. Our findings offer new insights into the mechanisms involved in fasting glucose homeostasis regulation in pregnancy, which is critical to understanding how gestational diabetes develops.

Details

Language :
English
ISSN :
22279059
Volume :
12
Issue :
6
Database :
Directory of Open Access Journals
Journal :
Biomedicines
Publication Type :
Academic Journal
Accession number :
edsdoj.bae7fa08ebb749ce8117b867cffec14a
Document Type :
article
Full Text :
https://doi.org/10.3390/biomedicines12061285