Back to Search Start Over

Gut microbiota signature of pathogen-dependent dysbiosis in viral gastroenteritis

Authors :
Taketoshi Mizutani
Samuel Yaw Aboagye
Aya Ishizaka
Theophillus Afum
Gloria Ivy Mensah
Adwoa Asante-Poku
Diana Asema Asandem
Prince Kofi Parbie
Christopher Zaab-Yen Abana
Dennis Kushitor
Evelyn Yayra Bonney
Motoi Adachi
Hiroki Hori
Koichi Ishikawa
Tetsuro Matano
Kiyosu Taniguchi
David Opare
Doris Arhin
Franklin Asiedu-Bekoe
William Kwabena Ampofo
Dorothy Yeboah-Manu
Kwadwo Ansah Koram
Abraham Kwabena Anang
Hiroshi Kiyono
Source :
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Abstract Acute gastroenteritis associated with diarrhea is considered a serious disease in Africa and South Asia. In this study, we examined the trends in the causative pathogens of diarrhea and the corresponding gut microbiota in Ghana using microbiome analysis performed on diarrheic stools via 16S rRNA sequencing. In total, 80 patients with diarrhea and 34 healthy adults as controls, from 2017 to 2018, were enrolled in the study. Among the patients with diarrhea, 39 were norovirus-positive and 18 were rotavirus-positive. The analysis of species richness (Chao1) was lower in patients with diarrhea than that in controls. Beta-diversity analysis revealed significant differences between the two groups. Several diarrhea-related pathogens (e.g., Escherichia-Shigella, Klebsiella and Campylobacter) were detected in patients with diarrhea. Furthermore, co-infection with these pathogens and enteroviruses (e.g., norovirus and rotavirus) was observed in several cases. Levels of both Erysipelotrichaceae and Staphylococcaceae family markedly differed between norovirus-positive and -negative diarrheic stools, and the 10 predicted metabolic pathways, including the carbohydrate metabolism pathway, showed significant differences between rotavirus-positive patients with diarrhea and controls. This comparative study of diarrheal pathogens in Ghana revealed specific trends in the gut microbiota signature associated with diarrhea and that pathogen-dependent dysbiosis occurred in viral gastroenteritis.

Subjects

Subjects :
Medicine
Science

Details

Language :
English
ISSN :
20452322
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Scientific Reports
Publication Type :
Academic Journal
Accession number :
edsdoj.bb2715808744f9a87b8c6f9257ebabc
Document Type :
article
Full Text :
https://doi.org/10.1038/s41598-021-93345-y