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Cutaneous Melanoma in Alpine Population: Incidence Trends and Clinicopathological Profile

Authors :
Alessandra Buja
Massimo Rugge
Giuseppe De Luca
Emanuela Bovo
Manuel Zorzi
Chiara De Toni
Claudia Cozzolino
Antonella Vecchiato
Paolo Del Fiore
Romina Spina
Sandro Cinquetti
Vincenzo Baldo
Carlo Riccardo Rossi
Simone Mocellin
Source :
Current Oncology, Vol 29, Iss 3, Pp 2165-2173 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Previous studies associated high-level exposure to ultraviolet radiation with a greater risk of cutaneous malignant melanoma (CMM). This study focuses on the changing incidence of CMM over time (from 1990 to 2017) in the Veneto region of Northeast Italy, and its Alpine area (the province of Belluno). The clinicopathological profile of CMM by residence is also considered. A joinpoint regression analysis was performed to identify significant changes in the yearly incidence of CMM by sex and age. For each trend, the average annual percent change (AAPC) was also calculated. In the 2017 CMM cohort, the study includes a descriptive analysis of the disease’s categorical clinicopathological variables. In the population investigated, the incidence of CMM has increased significantly over the last 30 years. The AAPC in the incidence of CMM was significantly higher among Alpine residents aged 0–49 than for the rest of the region’s population (males: 6.9 versus 2.4; females 7.7 versus 2.7, respectively). Among the Alpine residents, the AAPC was 3.35 times greater for females aged 0–49 than for people aged 50+. The clinicopathological profile of CMM was significantly associated with the place of residence. Over three decades, the Veneto population has observed a significant increase in the incidence of CMM, and its AAPC. Both trends have been markedly more pronounced among Alpine residents, particularly younger females. While epidemiology and clinicopathological profiles support the role of UV radiation in CMM, the young age of this CMM-affected female population points to other possible host-related etiological factors. These findings also confirm the importance of primary and secondary prevention strategies.

Details

Language :
English
ISSN :
17187729 and 11980052
Volume :
29
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Current Oncology
Publication Type :
Academic Journal
Accession number :
edsdoj.bb4652732774f7a94452dc4872a7175
Document Type :
article
Full Text :
https://doi.org/10.3390/curroncol29030175