The relationship between adenosine deaminase and heart rate-corrected QT interval in type 2 diabetic patients

Background: Prolonged heart rate-corrected QT (QTc) interval may reflect po or prognosis of patients with type 2 diabetes (T2D). Serum adenosine deamina se (ADA) levels are related to hyperglycemia, insulin resistance (IR) and inflammati on, which may participate in diabetic complications. We investigated the association of s erum ADA levels with prolonged QTc interval in a large-scale sample of patients with T2D. Methods: In this cross-sectional study, a total of 492 patients with T2 D were recruited. Serum ADA levels were determined by venous blood during fasting . QTc interval was estimated from resting 12-lead ECGs, and prolonged QTc interval was defined as QTc > 440 ms. Results: In this study, the prevalence of prolonged QTc interval was 22 .8%. Serum ADA levels were positively associated with QTc interval ( r = 0.324, P < 0.0001). The proportion of participants with prolonged QTc interval increased significan tly from 9.2% in the first tertile (T1) to 24.7% in the second tertile (T2) and 39.0% in t he third tertile (T3) of ADA (P for trend < 0.001). After adjusting for other possible risk fa ctors by multiple linear regression analysis, serum ADA level was still significantly ass ociated with QTc interval (β = 0.217, t = 3.400, P < 0.01). Multivariate logistic regression analysis showed that female (OR 5.084, CI 2.379–10.864, P < 0.001), insulin-sensitizers treatment (OR 4.229, CI 1.290–13.860, P = 0.017) and ADA (OR 1.212, CI 1.094–1.343, P < 0.001) were independent contributors to prolonged QTc interval. Conclusions: Serum ADA levels were independently associated with prolonged QTc interval in patients with T2D.