The value of autoantibody and D-dimer detection in evaluating the prognosis of patients with chronic hepatitis B and hepatitis B cirrhosis

Objective To detect autoantibodies and D-dimer in patients with chronic hepatitis B (CHB) or with hepatitis B cirrhosis (cirrhosis), and explore the value of detection in evaluating disease progression and prognosis of the patients. Methods A total of 147 consecutive cases meeting the enrollment criteria were collected in out hospital during January 2020 to January 2023, including 82 cases of CHB(CHB group) and 65 cases of cirrhosis(Cirrhosis group). Sixty healthy subjects were selected as the control, and autoantibody detection and D-dimer level were analyzed. In Cirrhosis group,patients died or suffered from digestive bleeding or hepatic encephalopathy were classified into poor prognosis group, and the other into good prognosis group. The autoantibody positivity and D-dimer level were included in binary logistic regression analysis to idetntify the risk factors for poor prognosis in patients with cirrhosis. Results The positive rate of autoantibody in CHB Group （25.61%）and Cirrhosis group （27.69%）were higher than that in control group（8.33%） (P