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In vitro cost-effective methods to detect carbapenemases in Enterobacteriaceae
- Source :
- Journal of Laboratory Physicians, Vol 10, Iss 01, Pp 101-105 (2018)
- Publication Year :
- 2018
- Publisher :
- Thieme Medical and Scientific Publishers Pvt. Ltd., 2018.
-
Abstract
- The rise in carbapenemases-producing organisms has challenged the scientific community. Infections caused by these bacteria have limited treatment options. There are various types such as Klebsiella pneumoniae carbapenemase (Ambler class A), metallo-beta-lactamases of VIM-type, IMP-type, NDM-type (Ambler class B), and OXA-48-types (Ambler class D). An efficient strategy for detection of carbapenemase producers is important to determine the appropriate therapeutic modalities. In this study, four methods - Carba NP test, modified Carba NP (MCNP) test, carbapenem inactivation method (CIM) test, and Rapidec Carba NP kit test were evaluated. We evaluated an in-house MCNP test to detect carbapenemase production using a single protocol which gave reliable results. Furthermore, CIM using routine antibiotic discs gives good results. Both these tests were found to be cost-effective.
- Subjects :
- carbapenemases
enterobacteriaceae
imipenem
Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 09742727 and 09747826
- Volume :
- 10
- Issue :
- 01
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Laboratory Physicians
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.bbff02b855f0475ab796f2304fae5c69
- Document Type :
- article
- Full Text :
- https://doi.org/10.4103/JLP.JLP_25_17