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Total Synthesis and Antidepressant Activities of Laetispicine and Its Derivatives
- Source :
- Molecules, Vol 17, Iss 2, Pp 1425-1436 (2012)
- Publication Year :
- 2012
- Publisher :
- MDPI AG, 2012.
-
Abstract
- The first total synthesis of laetispicine (1a), an amide alkaloid isolated from the stems of Piper laetispicum C.DC (Piperaceae), and the synthesis of some of its derivatives were described. Based on the evaluation of antidepressant activities in the forced swimming test, compounds 1h and 1i were identified as potent and safe antidepressant lead compounds.
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 17
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Molecules
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.bc32af057a0454baf539ae3a7339ddd
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/molecules17021425