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Chiral 1H NMR of Atropisomeric Quinazolinones With Enantiopure Phosphoric Acids
- Source :
- Frontiers in Chemistry, Vol 6 (2018)
- Publication Year :
- 2018
- Publisher :
- Frontiers Media S.A., 2018.
-
Abstract
- A chiral phosphoric acid promoted enantioselective NMR analysis of atropisomeric quinazolinones was described, in which a variety of racemic arylquinazolinones such as afloqualone and IC-87114 were well recognized with up to 0. 21 ppm ΔΔδ value. With this method, the optical purities of different non-racemic substrates can be fast evaluated with high accuracy.
Details
- Language :
- English
- ISSN :
- 22962646
- Volume :
- 6
- Database :
- Directory of Open Access Journals
- Journal :
- Frontiers in Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.bc3fcd3e0dc41cc8d0c56eb1df4ef56
- Document Type :
- article
- Full Text :
- https://doi.org/10.3389/fchem.2018.00300