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Staged developmental mapping and X chromosome transcriptional dynamics during mouse spermatogenesis
- Source :
- Nature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
- Publication Year :
- 2019
- Publisher :
- Nature Portfolio, 2019.
-
Abstract
- The transcriptional regulation of murine spermatogenesis is not well understood. Here, the authors use single-cell and bulk RNA-Sequencing of juvenile and adult mice to characterise somatic and germ cell development, and chromatin profile the X chromosome to show that spermatid-specific genes are repressed by H3K9me3 during meiosis.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 10
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.bc7e9055ff6e43a8ad2daf0f91f1d334
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-019-09182-1