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Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease.
- Source :
- PLoS Genetics, Vol 13, Iss 4, p e1006706 (2017)
- Publication Year :
- 2017
- Publisher :
- Public Library of Science (PLoS), 2017.
-
Abstract
- Recent advances in highly multiplexed immunoassays have allowed systematic large-scale measurement of hundreds of plasma proteins in large cohort studies. In combination with genotyping, such studies offer the prospect to 1) identify mechanisms involved with regulation of protein expression in plasma, and 2) determine whether the plasma proteins are likely to be causally implicated in disease. We report here the results of genome-wide association (GWA) studies of 83 proteins considered relevant to cardiovascular disease (CVD), measured in 3,394 individuals with multiple CVD risk factors. We identified 79 genome-wide significant (p
Details
- Language :
- English
- ISSN :
- 15537390 and 15537404
- Volume :
- 13
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- PLoS Genetics
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.bc8426e00b414c1fa9c00ba7d8da1ed8
- Document Type :
- article
- Full Text :
- https://doi.org/10.1371/journal.pgen.1006706