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Redesigning regulatory components of quorum-sensing system for diverse metabolic control

Authors :
Chang Ge
Zheng Yu
Huakang Sheng
Xiaolin Shen
Xinxiao Sun
Yifei Zhang
Yajun Yan
Jia Wang
Qipeng Yuan
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Existing quorum sensing (QS) circuits are less sophisticated for regulating multiple sets of genes or operons. Here, the authors redesign the luxR-luxI intergenic sequence of the lux-type QS system and apply it to achieve diverse metabolic control in salicylic acid and 4-hydroxycoumarin biosynthesis in E. coli.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.bcff024dde454193957aee281b8012c9
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-29933-x