Spatial transcriptomics landscape of lesions from non-communicable inflammatory skin diseases

Authors :: A. Schäbitz
C. Hillig
M. Mubarak
M. Jargosch
A. Farnoud
E. Scala
N. Kurzen
A. C. Pilz
N. Bhalla
J. Thomas
M. Stahle
T. Biedermann
C. B. Schmidt-Weber
F. Theis
N. Garzorz-Stark
K. Eyerich
M. P. Menden
S. Eyerich
Source :: Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Publication Year :: 2022
Publisher :: Nature Portfolio, 2022.
Abstract: Inflammatory skin diseases involve various different immune cells in a localised area. Here the authors use spatial transcriptomics to show that disease relevant cytokine transcripts are sparsely expressed in lesional skin, yet are associated with local amplification cascades that promote skin inflammation.

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