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Deficiency of PRKD2 triggers hyperinsulinemia and metabolic disorders
- Source :
- Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
- Publication Year :
- 2018
- Publisher :
- Nature Portfolio, 2018.
-
Abstract
- Hyperinsulinemia can precede the development of insulin resistance. Here the authors identify a PKD2 mutation that leads to hyperinsulinemia and insulin resistance in Rhesus monkey and show that PKD2 deficiency promotes beta cell insulin secretion by activating L-type Ca2+ channels.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 9
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.bdb7808618149698d196802ee3bf15d
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-018-04352-z