Clinical Application of a Novel Noninvasive Positive Pressure Ventilation Face Mask with Two Channels and Constant Leakage for Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease and Carbon Dioxide Retention

Background Noninvasive positive pressure ventilation (NPPV) is a major respiratory support technique for patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and carbon dioxide (CO2) retention. However, the obvious dead space in available masks used for NPPV could easily lead to repeated CO2 inhalation, which affects the correction of CO2 retention. Objective To develop a face mask with two channel and constant leakage (TCCL) used for NPPV, and to examine its value in NPPV treatment of AECOPD patients with CO2 retention. Methods Thirty patients with AECOPD and typeⅡ respiratory failure treated with NPPV were recruited from the ICU, the First Affiliated Hospital of Chongqing Medical University from 2020 to 2021, and equally randomized into an experimental group (using the TCCL mask) and an control group (using the traditional mask with an exhalation valve on the side for NPPV) . Treatment effectiveness was assessed using arterial partial pressure of oxygen (PaO2) and partial pressure of carbon dioxide (PaCO2) monitored at baseline, and at the end of 4, 8, 24, and 48 hours of NPPV treatment as well as 24 hours after NPPV cessation. Results The two-way repeated measures ANOVA indicated that treatment time and treatment approach had no interactive effects on PaO2 (P>0.05) . Treatment time produced significant main effects on PaO2 (P0.05) . Treatment time and treatment approach had no interactive effects on PaCO2 (P>0.05) . Treatment time produced significant main effect on PaCO2 (P