A general strategy for prepared multifunction double-ions agarose hydrogel dressing promotes wound healing

In this study, a new multifunctional double-ions macro-porous agarose hydrogel dressing is proposed, which successfully loaded Ag+ and Li+ simultaneously through the interaction of hydrogen bonds on carboxymethyl agarose (CMA) molecular chains and the interaction of carboxymethyl with metal ions. The macro-porous double-ions hydrogel dressing shows excellent biocompatibility, water-absorbing and water retention capabilities, as well as pH and temperature response characteristics. Moreover, Ag+ ions can be released in the early stage of treatment and Li+ ions can be released steadily and controlled for a long time throughout the treatment, which contributed to effectively antibacterial, and promote tissue regeneration, accelerate wound healing. Significantly, this work provides a general strategy for prepared multifunction double-ions hydrogel dressing with interconnected pores, not limited only to Ag+ and Li+ double-ions, but also Ag+ and Cu2+ double-ions, and Li+ and Cu2+ double-ions, and so on. Thus, the multifunction double-ions hydrogel exhibits a great potential in becoming an effective, efficient and economical wound management dressing. Moreover, this work presents a promising strategy in providing the agarose hydrogel wound dressing to achieve personalized customization ideas.