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Mammalian hibernation: a unique model for medical research
- Source :
- Frigid Zone Medicine, Vol 1, Iss 2, Pp 65-68 (2021)
- Publication Year :
- 2021
- Publisher :
- Sciendo, 2021.
-
Abstract
- Hibernation is an adaptive behavior for some small animals to survive cold winter. Hibernating mammals usually down-regulate their body temperature from ~37°C to only a few degrees. During the evolution, mammalian hibernators have inherited unique strategies to survive extreme conditions that may lead to disease or death in humans and other non-hibernators. Hibernating mammals can not only tolerant deep hypothermia, hypoxia and anoxia, but also protect them against osteoporosis, muscle atrophy, heart arrhythmia and ischemia-reperfusion injury. Finding the molecular and regulatory mechanisms underlying these adaptations will provide novel ideas for treating related human diseases.
Details
- Language :
- English
- ISSN :
- 27198073
- Volume :
- 1
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Frigid Zone Medicine
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.be90b576414b4dbfbd2b7fa2f9600a95
- Document Type :
- article
- Full Text :
- https://doi.org/10.2478/fzm-2021-0008