Back to Search
Start Over
Mucins, gut microbiota, and postbiotics role in colorectal cancer
- Source :
- Gut Microbes, Vol 13, Iss 1 (2021)
- Publication Year :
- 2021
- Publisher :
- Taylor & Francis Group, 2021.
-
Abstract
- An imbalance in the crosstalk between the host and gut microbiota affects the intestinal barrier function, which results in inflammatory diseases and colorectal cancer. The colon epithelium protects itself from a harsh environment and various pathogenic organisms by forming a double mucus layer, primarily comprising mucins. Recent studies are focusing on how dietary patterns alter the gut microbiota composition, which in turn regulates mucin expression and maintains the intestinal layers. In addition, modulation of gut microbiota by microbiotic therapy (involving fecal microbiota transplantation) has emerged as a significant factor in the pathologies associated with dysbiosis. Therefore, proper communication between host and gut microbiota via different dietary patterns (prebiotics and probiotics) is needed to maintain mucus composition, mucin synthesis, and regulation. Here, we review how the interactions between diet and gut microbiota and bacterial metabolites (postbiotics) regulate mucus layer functionalities and mucin expression in human health and disease.
Details
- Language :
- English
- ISSN :
- 19490976 and 19490984
- Volume :
- 13
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Gut Microbes
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.bea6ab93e3b47dfb06638516dcd14e5
- Document Type :
- article
- Full Text :
- https://doi.org/10.1080/19490976.2021.1974795