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Use of human fibrin glue (Tisseel) versus suture during transvaginal natural orifice ovarian cystectomy of benign and non-endometriotic ovarian tumor: a retrospective comparative study

Authors :
Yu-Ying Su
Yu-Shan Lin
Lan-Yan Yang
Yu-Bin Pan
Yi-Ting Huang
Cindy Hsuan Weng
Kai-Yun Wu
Chin-Jung Wang
Source :
BMC Surgery, Vol 21, Iss 1, Pp 1-8 (2021)
Publication Year :
2021
Publisher :
BMC, 2021.

Abstract

Abstract Background To evaluate the use of a human fibrin glue (Tisseel) for minor bleeding control and approximation of ovarian defect during transvaginal natural orifice ovarian cystectomy (TNOOC) of benign and non-endometriotic ovarian tumors. Methods A total of 125 women with benign and non-endometriotic ovarian tumors who underwent TNOOC between May 2011 and January 2020: 54 with the aid of Tisseel and 71 with traditional suture for hemostasis and approximation of ovarian defect. Surgical outcomes such as length of surgery, operative blood loss, postoperative pain score, and postoperative hospital stay were recorded. Before and immediately (10 days) and at 6 months after the procedure, serum anti-Müllerian hormone (AMH) levels were also determined. Results Complete hemostasis and approximation of ovarian defect were achieved in all cases. No significant difference was noted in the operating time, operative blood loss, postoperative pain scores after 12, 24 and 48 h, length of postoperative stay, and baseline AMH levels between the two groups. The operation did not have a negative effect on the immediate and 6-month postoperative AMH levels in the suture group. However, the decline in the AMH levels was significant immediately after surgery in the Tisseel group, nevertheless, no significant difference was noted in the AMH levels at 6 months (3.3 vs. 1.7 mg/mL; p = 0.042, adjusted p = 0.210). Conclusion The use of Tisseel in TNOOC of benign and non-endometriotic ovarian tumors without suturing the ovarian tissue is clinically safe and feasible.

Details

Language :
English
ISSN :
14712482
Volume :
21
Issue :
1
Database :
Directory of Open Access Journals
Journal :
BMC Surgery
Publication Type :
Academic Journal
Accession number :
edsdoj.bedb6c47df4f428682f3d9940ee7e9b1
Document Type :
article
Full Text :
https://doi.org/10.1186/s12893-021-01061-1