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Complex interaction of dietary fat and Alaskan bog blueberry supplementation influences manganese mediated neurotoxicity and behavioral impairments

Complex interaction of dietary fat and Alaskan bog blueberry supplementation influences manganese mediated neurotoxicity and behavioral impairments

Authors :
Malabika Maulik
Swarup Mitra
McKenzie Sweeney
Brianna Lu
Barbara E. Taylor
Abel Bult-Ito
Source :
Journal of Functional Foods, Vol 53, Iss , Pp 306-317 (2019)
Publication Year :
2019
Publisher :
Elsevier, 2019.

Abstract

Dietary fat modulates neuronal health and contributes to age-related nervous system disorders. However, the complex interaction between dietary fat and supplementation and its consequences on neurotoxic pathophysiology has been sparsely explored. The indigenous Alaskan bog blueberry (BB), Vaccinum uliginosum, is known to have anti-inflammatory properties, mostly attributed to its rich polyphenolic content. Here, we evaluate the interplay between dietary fat and BB supplementation on sub-chronic manganese (Mn) exposure that inflicts neurotoxicity and behavioral impairments. In both low-fat and normal-fat diets, BB supplementation attenuated the behavioral and the molecular hallmarks of Mn-induced neurotoxicity. On the contrary, a high-fat diet was found to exacerbate these Mn-induced pathological features. Furthermore, BB supplementation failed to recover the behavioral deficits in mice subjected to a high fat diet in Mn-treated mice. Overall, our results demonstrate the importance of including a dietary regimen comprised of polyphenolic rich supplements with low-fat content in combating age-related neurodegenerative disorders.

Details

Language :
English
ISSN :
17564646
Volume :
53
Issue :
306-317
Database :
Directory of Open Access Journals
Journal :
Journal of Functional Foods
Publication Type :
Academic Journal
Accession number :
edsdoj.bedfe3133f3346e99b0ab6c5684bc128
Document Type :
article
Full Text :
https://doi.org/10.1016/j.jff.2018.12.028