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Cancer stem cells: a target for overcoming therapeutic resistance and relapse
- Source :
- Cancer Biology & Medicine, Vol 20, Iss 12, Pp 985-1020 (2023)
- Publication Year :
- 2023
- Publisher :
- China Anti-Cancer Association, 2023.
-
Abstract
- Cancer stem cells (CSCs) are a small subset of cells in cancers that are thought to initiate tumorous transformation and promote metastasis, recurrence, and resistance to treatment. Growing evidence has revealed the existence of CSCs in various types of cancers and suggested that CSCs differentiate into diverse lineage cells that contribute to tumor progression. We may be able to overcome the limitations of cancer treatment with a comprehensive understanding of the biological features and mechanisms underlying therapeutic resistance in CSCs. This review provides an overview of the properties, biomarkers, and mechanisms of resistance shown by CSCs. Recent findings on metabolic features, especially fatty acid metabolism and ferroptosis in CSCs, are highlighted, along with promising targeting strategies. Targeting CSCs is a potential treatment plan to conquer cancer and prevent resistance and relapse in cancer treatment.
Details
- Language :
- English
- ISSN :
- 20953941
- Volume :
- 20
- Issue :
- 12
- Database :
- Directory of Open Access Journals
- Journal :
- Cancer Biology & Medicine
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.bf882fc2f4214065abe0ab1e03e9288b
- Document Type :
- article
- Full Text :
- https://doi.org/10.20892/j.issn.2095-3941.2023.0333