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JC Polyomavirus Nephropathy: A Rare Complication Late after Kidney Transplantation
- Source :
- Case Reports in Nephrology and Dialysis, Vol 14, Iss 1, Pp 148-157 (2024)
- Publication Year :
- 2024
- Publisher :
- Karger Publishers, 2024.
-
Abstract
- Introduction: JC-polyomavirus-associated nephropathy (JC-PVAN) is a rare cause of allograft dysfunction with only a few cases described in the literature. Case Presentation: We present 2 cases of JC-PVAN, both of which occurred >5 years after kidney transplantation. In both cases, transplant biopsies were performed because of worsening of kidney function. We found tubulitis and interstitial inflammation; immunohistochemistry was positive for SV40, but BK virus was not detected. The presence of JC virus confirmed the diagnosis of JC-PVAN. Immunosuppressive therapy was adopted, but in both cases graft function progressively deteriorated. Conclusions: Our cases show that JC-PVAN, although much rarer than BK-PVAN, should be considered a possible cause of graft dysfunction even years after transplantation. Complete diagnostic workup, including kidney biopsy, is crucial for correct diagnosis and treatment.
Details
- Language :
- English
- ISSN :
- 22969705
- Volume :
- 14
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Case Reports in Nephrology and Dialysis
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.bfdd9e3e396b410d9ae11a61ff5305c5
- Document Type :
- article
- Full Text :
- https://doi.org/10.1159/000540294