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Twenty-four-hour and office blood pressure measurement in a comprehensive assessment of the effectiveness of 12-week therapy with a triple fixed-dose combination of amlodipine/indapamide/perindopril in hypertensive patients in actual clinical practice
- Source :
- Российский кардиологический журнал, Vol 26, Iss 5 (2021)
- Publication Year :
- 2021
- Publisher :
- «FIRMA «SILICEA» LLC, 2021.
-
Abstract
- Aim. To study the efficacy and safety of the triple fixed-dose combination (FDC) of amlodipine/indapamide/perindopril on blood pressure (BP) profile in patients with grade I-II hypertension (HTN) in actual clinical practice.Material and methods. Data from 54 patients with paired 24-hour ambulatory BP monitoring (ABPM) data were included in the TRICOLOR subanalysis (ClinicalTrials. gov study ID — NCT03722524). The mean 24-hour, daytime, and nighttime BP were calculated at baseline and after 12-week follow-up. We determined the proportion of patients with nocturnal HTN (≥120/70 mm Hg) and nocturnal hypotension (20%), as well as those without nocturnal BP decrease (>0%, non-dipper (ND)). The smoothness index (SI) was analyzed as the ratio of the mean hourly SBP fall to its mean standard deviation in paired ABPM. To assess the BP phenotypes, two methods were used with reference values of
Details
- Language :
- Russian
- ISSN :
- 15604071 and 26187620
- Volume :
- 26
- Issue :
- 5
- Database :
- Directory of Open Access Journals
- Journal :
- Российский кардиологический журнал
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f03665545ac748f797d3779302221331
- Document Type :
- article
- Full Text :
- https://doi.org/10.15829/1560-4071-2021-4498