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Severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration: a prospective cross-sectional study

Authors :
Manina M. Etter
Tomás A. Martins
Laila Kulsvehagen
Elisabeth Pössnecker
Wandrille Duchemin
Sabrina Hogan
Gretel Sanabria-Diaz
Jannis Müller
Alessio Chiappini
Jonathan Rychen
Noëmi Eberhard
Raphael Guzman
Luigi Mariani
Lester Melie-Garcia
Emanuela Keller
Ilijas Jelcic
Hans Pargger
Martin Siegemund
Jens Kuhle
Johanna Oechtering
Caroline Eich
Alexandar Tzankov
Matthias S. Matter
Sarp Uzun
Özgür Yaldizli
Johanna M. Lieb
Marios-Nikos Psychogios
Karoline Leuzinger
Hans H. Hirsch
Cristina Granziera
Anne-Katrin Pröbstel
Gregor Hutter
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Both acute and chronic COVID-19 disease (also known as long-COVID) may affect the central nervous system. Here authors characterize the immunological profile of peripheral blood and cerebrospinal fluid of COVID-19 patients in order to identify the main factors that contribute to neurological impairment and the severity of neurological symptoms in Sars-CoV-2 infection.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.f0470cc90c504832a493429d193b5b41
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-34068-0