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Gut microbiota diversity after autologous fecal microbiota transfer in acute myeloid leukemia patients

Authors :
Florent Malard
Anne Vekhoff
Simona Lapusan
Francoise Isnard
Evelyne D’incan-Corda
Jérôme Rey
Colombe Saillard
Xavier Thomas
Sophie Ducastelle-Lepretre
Etienne Paubelle
Marie-Virginie Larcher
Clément Rocher
Christian Recher
Suzanne Tavitian
Sarah Bertoli
Anne-Sophie Michallet
Lila Gilis
Pierre Peterlin
Patrice Chevallier
Stéphanie Nguyen
Emilie Plantamura
Lilia Boucinha
Cyrielle Gasc
Mauricette Michallet
Joel Dore
Ollivier Legrand
Mohamad Mohty
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

The combination of chemotherapy and broad-spectrum antibiotics induces gut microbiota (GM) dysbiosis in acute myeloid leukaemia (AML) leading to additional complications. Here, the authors report the efficacy in GM restoration and safety of autologous faecal microbiota transfer in treated AML patients in a phase II clinical trial.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.f0565b9c6bfc48c0b52d42791181b41c
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-23376-6