Back to Search Start Over

Study of serum and urinary markers of the reninangiotensin-aldosterone system in myelomeningocele patients with renal injury detected by DMSA

Study of serum and urinary markers of the reninangiotensin-aldosterone system in myelomeningocele patients with renal injury detected by DMSA

Authors :
Cássia Maria Carvalho Abrantes do Amaral
Dulce Elena Casarini
Maria Cristina Andrade
Marcela Leal da Cruz
Antônio Macedo
Source :
International Brazilian Journal of Urology, Vol 46, Iss 5, Pp 805-813 (2020)
Publication Year :
2020
Publisher :
Sociedade Brasileira de Urologia, 2020.

Abstract

ABSTRACT Introduction: The Renin-Angiotensin-Aldosterone System (RAAS) has been suggested as a possible marker of renal injury in chronic diseases. This study proposes to analyze the serum and urinary markers of the RAAS in myelomeningocele patients with renal function abnormalities detected on DMSA. Material and Methods: Seventeen patients followed in our institution that presented with renal injury on DMSA. We review nephrologic and urologic clinical aspects and evaluated ultrassonagraphy, voiding urethrocystography and urodynamics. Urinary and serum samples were collected to evaluate possible correlations of renal lesions with RAAS. Control group urine and serum samples were also sent for analysis. Results: Serum ACE 2 activity means in relation to urodynamic findings were the only values that had a statistically significant difference (p = 0.040). Patients with normal bladder pattern presented higher ACE 2 levels than the high risk group. Statistical analysis showed that the study group (SG) had a significantly higher mean serum ACE than the CG. The means of ACE 2 and urinary ACE of the SG and CG were not statistically different. The ROC curve for serum ACE values had a statistically significant area for case and non-case differentiation, with 100% sensitivity and 53% specificity for values above 60.2 mg/dL. No statistically significant areas were observed in relation to ACE 2 and urinary ACE values between SG and CG. Conclusion: The analysis of serum ACE, ACE 2 and urinary ACE were not significant in patients with myelomeningocele and neurogenic bladder with renal injury previously detected by renal DMSA.

Details

Language :
English
ISSN :
16776119 and 16775538
Volume :
46
Issue :
5
Database :
Directory of Open Access Journals
Journal :
International Brazilian Journal of Urology
Publication Type :
Academic Journal
Accession number :
edsdoj.f07f6e8cc71d4cfe97cdebfcaf2373cc
Document Type :
article
Full Text :
https://doi.org/10.1590/s1677-5538.ibju.2019.0797