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The Role of p16, p21, p27, p53 and Ki-67 Expression in the Differential Diagnosis of Cutaneous Squamous Cell Carcinomas and Keratoacanthomas: An Immunohistochemical Study
- Source :
- Balkan Medical Journal, Vol 33, Iss 2, Pp 121-127 (2016)
- Publication Year :
- 2016
- Publisher :
- Galenos Publishing House, 2016.
-
Abstract
- Background: Distinguishing squamous cell carcinoma (SCC) from keratoacanthoma (KA) by histopathological features may not be sufficient for a differential diagnosis, as KAs may, in some cases, imitate well-differentiated SCCs. Aims: In this study, we investigated whether the expression of the p16, p21, p27, p53 genes and a Ki-67 proliferation index are useful in distinguishing between these two tumors. Study Design: Cross-sectional study. Methods: Immunohistochemistry was used to investigate the expression of the p16, p21, p27, p53 genes and the Ki-67 proliferation index was investigated in well-differentiated SCC with KA-like features (n=40) and KA (n=30). Results: The results of all of the examined markers, except for p27 (p16, p21, p53, and Ki-67) were found to be significantly different between the SCC and KA samples (p
Details
- Language :
- English
- ISSN :
- 21463123 and 21463131
- Volume :
- 33
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Balkan Medical Journal
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f18423772ca54d7c8cb956210d1469a1
- Document Type :
- article
- Full Text :
- https://doi.org/10.5152/balkanmedj.2016.16442