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Lymphatic endothelial cells prime naïve CD8+ T cells into memory cells under steady-state conditions
- Source :
- Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
- Publication Year :
- 2020
- Publisher :
- Nature Portfolio, 2020.
-
Abstract
- Lymphatic endothelial cells (LECs) can cross-present antigen to naïve CD8+ T cells, but the significance of this interaction was unclear. Here the authors show that LECs directly induce CD8+ T cell differentiation with memory-like phenotypes, migration patterns and transcriptome, which can later be recalled to promote effector immunity and protection from Listeria infection.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 11
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f23b98b899c044b5baa15c4c746b6da2
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-019-14127-9