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Sex-specific differences in transcriptomic profiles and cellular characteristics of oligodendrocyte precursor cells
- Source :
- Stem Cell Research, Vol 46, Iss , Pp 101866- (2020)
- Publication Year :
- 2020
- Publisher :
- Elsevier, 2020.
-
Abstract
- The susceptibility to neurological and psychiatric disorders reveals sexual dimorphism in the structure and function of human brains. Recent evidence has also demonstrated the sex-related differences in cellular components of the brain, including neurons, microglia, astrocytes, and endothelial cells. Oligodendrocyte precursor cells (OPCs) regulate the neuronal system in various ways and play crucial roles in brain homeostasis beyond their well-known role as a reservoir for mature oligodendrocytes. Although recent studies have shown regional diversities and heterogeneities of OPCs, sex-related differences in OPCs are largely unknown. Here, we revealed transcriptomic differences in OPCs isolated from male and female neonatal rat brains. Furthermore, we demonstrated sex-dependent differences in OPCs regarding proliferation, migration, differentiation, tolerance against ischemic stress, energy metabolism, and the ability to regulate the blood–brain barrier integrity.
Details
- Language :
- English
- ISSN :
- 18735061
- Volume :
- 46
- Issue :
- 101866-
- Database :
- Directory of Open Access Journals
- Journal :
- Stem Cell Research
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f2463fbeed364cddaa98e702ac45f2a1
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.scr.2020.101866