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Targeting tumor vulnerabilities associated with loss of heterozygosity
- Source :
- Molecular & Cellular Oncology, Vol 7, Iss 4 (2020)
- Publication Year :
- 2020
- Publisher :
- Taylor & Francis Group, 2020.
-
Abstract
- We show that N-acetyltransferase 2 (NAT2) loss of heterozygosity can be targeted in >4% of colorectal cancers with the use of a small molecule. We identify and describe the effect of a compound that impairs the growth of colorectal tumors with slow NAT2 activity by half when compared to wild-type.
Details
- Language :
- English
- ISSN :
- 23723556
- Volume :
- 7
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Molecular & Cellular Oncology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f26f6a1f8d8642699b7d0821aa9737a7
- Document Type :
- article
- Full Text :
- https://doi.org/10.1080/23723556.2020.1759390