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Omics analysis of Mycobacterium tuberculosis isolates uncovers Rv3094c, an ethionamide metabolism-associated gene

Authors :
Li Wan
Peilei Hu
Lili Zhang
Zhao-Xi Wang
Joy Fleming
Bo Ni
Jianjun Luo
Cha-Xiang Guan
Liqiong Bai
Yunhong Tan
Haican Liu
Na Li
Tongyang Xiao
Hua Bai
Yong-An Zhang
Xian-En Zhang
Kanglin Wan
Lijun Bi
Songying Ouyang
Hongtai Zhang
Source :
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

A multi-omic analysis of 11 Mycobacterium tuberculosis (Mtb) isolates with different drug resistance profiles leads to the discovery of Rv3094c, an enzyme capable of activating the clinically relevant Mtb drug, ethionamide.

Subjects

Subjects :
Biology (General)
QH301-705.5

Details

Language :
English
ISSN :
23993642
Volume :
6
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Communications Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.f339eb7018594782a51c882f29bbd3d8
Document Type :
article
Full Text :
https://doi.org/10.1038/s42003-023-04433-w