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Evaluation of immunotoxicity of the extended-release form of Afobazol

Authors :
L. P. Kovalenko
R. V. Zhurikov
K. V. Korzhova
A. D. Durnev
Source :
Фармакокинетика и Фармакодинамика, Vol 0, Iss 3, Pp 48-51 (2021)
Publication Year :
2021
Publisher :
LLC “Publisher OKI”, 2021.

Abstract

The research of immunotoxicity of extended-release form of Afobazol was conducted on male CBA, C57BL/6 and F1 hybrids (CBA×C57BL/6) mice. Afobazol was administered per os for 14 days in doses of 12 mg/kg and 120 mg/kg. Control group received a placebo. Weight of thymus, spleen and popliteal lymph nodes was not affected by the extended-release form of Afobazol in doses of 12 mg/kg and 120 mg/kg in F1 hybrids (CBA×C57BL/6) mice compared to the control group (p> 0.05). Cellularity of thymus was significantly increased by the extended-release form of Afobazol in dose of 12 mg/kg (p< 0.01 vs control group). Administration of the extended-release form of Afobazol in doses of 12 mg/kg and 120 mg/kg decreased spontaneous chemiluminescence activity of peripheral blood lymphocytes in 2.0 and 2.2 times, in dose of 120 mg/kg level integral chemiluminescence response S was decreased in 2.4 times (p< 0.05 vs control group). Phagocytic activity of peritoneal macrophages and antibody production in F1 hybrids (CBA×C57BL/6) mice were not affected by administration of the extended-release form of Afobazol in doses of 12 mg/kg and 120 mg/kg (p > 0.05 vs control group). 14 days of the extended-release form of Afobazol in doses of 12 mg/kg and 120 mg/kg did not cause any significant change to intensity of delayed-type hypersensitivity reactions (p> 0.05 vs control group). The results of the study allow us to conclude that administration of the extended-release form Afobazol in the range of studied doses does not induce immunotoxicity.

Details

Language :
Russian
ISSN :
25877836 and 26868830
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Фармакокинетика и Фармакодинамика
Publication Type :
Academic Journal
Accession number :
edsdoj.f378ef3cd2c04998b42f5427bc3e74a7
Document Type :
article
Full Text :
https://doi.org/10.37489/2587-7836-2020-3-48-51