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Simultaneous Determination of nicotinamide, kojic acid, Tranexamic acid, raspberry glycoside, azelaic acid, magnesium ascorbate phosphate and β-Arbutin in whitening cosmetics by UPLC-MS/MS

Authors :
Zou Xiao
Yan Lixiu
Luo Xiaofang
Wang Enting
Zhang Mingjuan
Huang Wuping
Li Wulin
Tong Lanyan
Source :
MATEC Web of Conferences, Vol 380, p 01005 (2023)
Publication Year :
2023
Publisher :
EDP Sciences, 2023.

Abstract

A UPLC-MS/MS method was developed for simultaneous determination of 7 whitening ingredients: nicotinamide, kojic acid, Tranexamic acid, raspberry glycoside, azelaic acid, magnesium ascorbate phosphate and β-Arbutin in cosmetics. The whitening active components were extracted from cosmetics by supersonic extraction with sodium chloride and dichloromethane to disperse the sample, and supersonic extraction with 0.015 mol/L potassium dihydrogen phosphate solution purified by HLB solid phase extraction column, scanned and detected by electrospray ionization source with positive and negative ion alternate scanning mode and multiple reaction monitoring mode. The results showed that the whitening active ingredients were separated within 3 minutes, with a good linear relationship (R>0.999), and the detection limit was 0.10mg/kg~0.75mg/kg. The recoveries (n=6) were 78.84%-104.85%, and the RSDs were 0.24%-11.35%. This method is suitable for the rapid determination of whitening active ingredients in cosmetics.

Details

Language :
English, French
ISSN :
2261236X
Volume :
380
Database :
Directory of Open Access Journals
Journal :
MATEC Web of Conferences
Publication Type :
Academic Journal
Accession number :
edsdoj.f3b73251f1c54b53a111348aed7c918f
Document Type :
article
Full Text :
https://doi.org/10.1051/matecconf/202338001005