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METTL14 is required for exercise-induced cardiac hypertrophy and protects against myocardial ischemia-reperfusion injury

Authors :
Lijun Wang
Jiaqi Wang
Pujiao Yu
Jingyi Feng
Gui-e Xu
Xuan Zhao
Tianhui Wang
H. Immo Lehmann
Guoping Li
Joost P. G. Sluijter
Junjie Xiao
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

The benefit of regular exercise on the heart has been well documented but the role of RNA m6A modification in exercise-induced cardiac remodelling remains largely unknown. In this study, the authors report that METTL14 plays an important role in RNA m6A modification in exercise-induced physiological cardiac hypertrophy.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.f3bda8f19ff54730a4083c563cec8318
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-34434-y