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Association between dysbiotic perio-pathogens and inflammatory initiators and mediators in COVID-19 patients with diabetes

Authors :
Endang W. Bachtiar
Boy M. Bachtiar
Ardiana Kusumaningrum
Hari Sunarto
Yuniarti Soeroso
Benso Sulijaya
Citra Fragrantia Theodorea
Irandi Putra Pratomo
Yudhistira
Defi Efendi
Efa Apriyanti
Shahida Mohd Said
Source :
Heliyon, Vol 10, Iss 2, Pp e24089- (2024)
Publication Year :
2024
Publisher :
Elsevier, 2024.

Abstract

It has been suggested that a corona virus infection is linked to chronic periodontitis (COVID-19). Our objectives were to look at the expression of angiotensin-converting enzyme-2 (ACE2) in periodontal compartments containing periodontal infections to determine if ACE2 is directly or indirectly responsible for the inflammation in periodontal tissues getting worse. In this study, six non-COVID-19 periodontitis patients without diabetes served as controls, and 23 hospitalized periodontitis patients were admitted with PCR-confirmed COVID-19 with diabetes mellitus (Group 1/G1, n = 10), and without diabetes (Group 2/G2, n = 13). We evaluated the mRNA expression of ACE2, IL-6, IL-8, complement C3, and LL-37, as well as the relative proportion of Porphyromonas gingivalis, Fusobacterium nucleatum, and Veillonella parvula to represent the dysbiosis condition in periodontal microenvironment using subgingival plaque and gingival crevicular fluids (GCF) samples and quantitative real time PCR (qPCR). Every analysis was done to ascertain how they related to one another. The area under the curve (AUC) and receiver operating characteristic (ROC) curve were used to determine the sensitivity and specificity of inflammatory indicators. All the grouped patients had ACE2 detected, according to our findings, but only the G1 patients had a positive correlation (p

Details

Language :
English
ISSN :
24058440
Volume :
10
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Heliyon
Publication Type :
Academic Journal
Accession number :
edsdoj.f4151a70af02458182fa7a66ce6db5c1
Document Type :
article
Full Text :
https://doi.org/10.1016/j.heliyon.2024.e24089