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Nigrodiquinone A, a Hydroanthraquinone Dimer Containing a Rare C-9–C-7′ Linkage from a Zoanthid-Derived Nigrospora sp. Fungus

Authors :
Wei-Feng Xu
Xue-Mei Hou
Kai-Lin Yang
Fei Cao
Rui-Yun Yang
Chang-Yun Wang
Chang-Lun Shao
Source :
Marine Drugs, Vol 14, Iss 3, p 51 (2016)
Publication Year :
2016
Publisher :
MDPI AG, 2016.

Abstract

One new hydroanthraquinone dimer with a rare C-9–C-7′ linkage, nigrodiquinone A (1), and four known anthraquinone monomers 2–5, were isolated from a fungus Nigrospora sp. obtained from the zoanthid Palythoa haddoni collected in the South China Sea. The structure of 1 was established through extensive NMR spectroscopy, and the absolute configuration was elucidated by comparing computed electronic circular dichroism (ECD) and optical rotations (OR) with experimental results. All the compounds were evaluated for antiviral activity, and 1 was also evaluated for antibacterial activity. Compound 4 displayed mild antiviral activity against coxsackie virus (Cox-B3) with the IC50 value of 93.7 μM, and 5 showed an IC50 value of 74.0 μM against respiratory syncytial virus (RSV).

Details

Language :
English
ISSN :
16603397
Volume :
14
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Marine Drugs
Publication Type :
Academic Journal
Accession number :
edsdoj.f452b2fb7c2456686aaf8bd1cb2f407
Document Type :
article
Full Text :
https://doi.org/10.3390/md14030051