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Self-assembly nanoplatform of platinum (Ⅳ) prodrug for enhanced ovarian cancer therapy
- Source :
- Materials Today Bio, Vol 21, Iss , Pp 100698- (2023)
- Publication Year :
- 2023
- Publisher :
- Elsevier, 2023.
-
Abstract
- Cisplatin is a metal platinum complex commonly used in the field of anti-tumor and one of the most commonly used drugs in combination chemotherapy. However, chemotherapy with Cisplatin induced overexpression of cyclooxygenase-2 (COX-2) protein in tumor cells, which could impair the therapeutic effect of chemotherapy on tumor progression. Here, we presented a novel method for the treatment of ovarian cancer with a self-assembly based nano-system. Cisplatin and tolfenamic acid were each linked to linoleic acid to give them the ability to self-assemble into nanoparticles in water. TPNPs had flexible drug ratio adjustability, homogeneous stability, and high drug loading capacity. Compared with Cisplatin, TPNPs could promote cellular uptake and tumor aggregation, co-induce enhanced apoptosis and tumor growth inhibition by inhibiting COX-2 in the mice xenograft model of human ovarian cancer, and reduce systemic toxicity. Therefore, TPNPs is a promising antitumor drug as a kind of self-assembly nano-prodrug with high drug load.
Details
- Language :
- English
- ISSN :
- 25900064
- Volume :
- 21
- Issue :
- 100698-
- Database :
- Directory of Open Access Journals
- Journal :
- Materials Today Bio
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f46215130d4041e7b5d1131c8dd545e0
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.mtbio.2023.100698