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Current progress in the synthesis of imidazoles and their derivatives via the use of green tools
- Source :
- Heterocyclic Communications, Vol 30, Iss 1, Pp 6311-25 (2024)
- Publication Year :
- 2024
- Publisher :
- De Gruyter, 2024.
-
Abstract
- Imidazoles have a unique position in heterocyclic chemistry as these constitute the basic framework of several bio-molecules. Thus, increasing research is being carried out on the synthesis of imidazoles and their derivatives, mainly because of the application of imidazoles in pharmaceutical and medicinal research. Keeping sustainability in mind, researchers are developing synthetic pathways for the synthesis of imidazoles and their derivatives by employing techniques involving green tools, thus leading to sustainable pathways. In this review, we aim to compile such synthetic methodologies involving green tools for the synthesis of imidazoles. The review will cover the synthetic reactions that involve green tools such as microwave irradiation, ultrasound irradiation, and ball milling. We aim to highlight the scope and relevance of such green tools in today’s synthetic research. Through this review, we wish to contribute towards the synthesis of imidazoles that serve as a useful class of heterocyclic compounds involved in the development of pharmaceutically active molecules. We sincerely hope that this review will serve as a relevant guide for future sustainable research in the synthesis of imidazoles and their derivatives.
- Subjects :
- heterocycles
imidazoles
microwave
ultrasound
ball milling
Organic chemistry
QD241-441
Subjects
Details
- Language :
- English
- ISSN :
- 21910197
- Volume :
- 30
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Heterocyclic Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f4868bb3bbb4a7da8196a5b66f666d8
- Document Type :
- article
- Full Text :
- https://doi.org/10.1515/hc-2022-0175